Sharaxaad Gaaban:
Lambarka CAS: 472-15-1
Qaacidada molecular:C30H48O3
miisaanka kelli: 456.71
Qaab dhismeedka kiimikada:
| Macluumaadka aasaasiga ah | |
| Magaca alaabta | Betulinic acid |
| Darajo | darajada farmashiyaha |
| Muuqashada | Cadaan ama mid cad |
| Qiimayn | 98% |
| Nolosha shelf | 2 sano |
| Baakad | 25kg/durbaan |
| Xaalad | Deggan, laakiin kaydi qabow. Aan ku habboonayn wakiilada oksaydhiyeyaasha xooggan, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, fitamiinada kooxda B ee sodium. |
Sharaxaada
Betulinic acid (472-15-1) waa Lupane triterpenoid dabiici ah oo ka yimid geed bjørk cad (Betula pubescens). Waxay keentaa apoptosis ee xadhkaha unugyada kala duwan.1 Waxay keentaa daloolada kala-guurka ee mitochondrial permeability.2
Isticmaal
Betulinic acid waa triterpenoid pentacyclic dabiiciga ah. Betulinic acid waxay muujisaa firfircoonida ka hortagga bararka iyo ka hortagga HIV. Betulinic Acid waxay si door ah u kicisaa apoptosis unugyada burooyinka iyadoo si toos ah u dhaqaajisa dariiqa mitirka ee apoptosis iyada oo loo marayo habka p53- iyo CD95-madax banaan. Betulinic acid waxay sidoo kale muujisaa waxqabadka agonist TGR5.
Betulinic acid (BetA) ayaa loo isticmaalay:
1.si loo tijaabiyo saamaynteeda sida wakiilka fayraska ka hortaga fayraska Dengue (DENV).
2.sida sterol regulatory element-binding protein (SREBP) inhibitor si loo xakameeyo dheef-shiid kiimikaadka dufanka leh iyo kordhinta unugyada cad ee kansarka unugyada kelyaha (ccRCC).
3. sida daawaynta si loo tijaabiyo hantideeda ka hortagga burooyinka ee jiritaanka unugyada iyo baaritaanka dhimashada unugyada apoptotic ee noocyo badan oo myeloma ah.
Cilmi-baarista Kansarka
Xaruntani waa triterpene pentacyclic ah oo laga helay noocyada Betula iyo Zizyphus, taas oo muujinaysa cytotoxicity ee xulashada unugyada melanoma ee bini'aadamka (Shoeb2006). Waxay abuurtaa noocyada oksijiinta falceliska ah, waxay kicisaa MAPK cascade, inhibitstopoisomerase I, waxay joojisaa angiogenesis, waxay wax ka beddeshaa transcriptionalactivators pro-koritaanka, waxay wax ka beddeshaa waxqabadka aminopeptidase-N, oo markaa ku dhalisa unugyada kansarka (Desai et al. 2008; Fulda 2008).
Waxqabadka Nafleyda
Triterpenoid-dabiiciga ah oo muujiya ka-hortagga HIV iyo waxqabadka antitumor. Waxay kicisaa soo saarista noocyada ogsijiinta falcelinta (ROS) waxayna dhaqaajisaa NF-κ B. Waxay muujisaa waxqabadka agonist TRG5 (EC 50 = 1.04 μM).
Waxqabadyada Biochem/physiol
Betulinic acid, triterpene pentacyclic, ayaa si door ah u kicisa apoptosis ee unugyada burooyinka iyadoo si toos ah u dhaqaajisa dariiqa mitirka ee apoptosis iyada oo loo marayo habka p53- iyo CD95-madax banaan.
