Sharaxaad Gaaban:
Lambarka CAS: 54965-21-8
Qaaciddada molecular: C12H15N3O2S
Miisaanka molecular: 265.333
Qaab dhismeedka kiimikada:
Sharaxaada
Albendazole (ALBENZA) waa anthelmintic ballaaran oo afka laga qaato.Kiniiniga Albendazole la ruugi karo waxa lagu daray Ururka Caafimaadka Adduunka (WHO) ee liiska dawooyinka muhiimka ah sida anthelminthic-ka mindhicirka iyo dawada lidka-filaariyada.Kiniinka Albendazole waxa soo saaray SmithKline Sheybaarada Caafimaadka Xoolaha waxaana ansixiyay Maamulka Cuntada iyo Dawooyinka ee Maraykanka (FDA) 1996kii.
Albendazole waxa uu awood u leeyahay in uu si buuxda u dilo ukumaha whipworm iyo hookworm iyo sidoo kale qayb ahaan in uu dilo ukumaha Ascaris;Waxa kale oo ay ka takhalusi kartaa noocyo kala duwan oo nematodes ah oo ku dulman gudaha jidhka xayawaanka, waxayna saameyn ku leedahay in laga takhaluso ama si toos ah u dilo gooryaanka iyo cysticerci.Sidaas awgeed waa faa'iido u leh daaweynta hydatid iyo habdhiska dareenka (cysticercosis) oo ay keento caabuqa gooryaanka doofaarka, iyo sidoo kale daaweynta hookworm, roundworm, pinworm, nematode trichinella, tapeworm, whipworm iyo stercoralis nematode.
Pharmacodynamics
Albendazole waa nooc ka mid ah derivatives benzimidazole.Waxaa si degdeg ah loo metabolized gudaha vivo galay sulfoxide, sulfone iyo 2-polyamine sulfone aalkolo.Waxay si door ah oo aan leexleexad lahayn u joojin kartaa qaadashada gulukooska ee nematodes-ka mindhicirka, taas oo keenta in glycogen endogenous ee gooryaanka;Isla mar ahaantaana, waxay sidoo kale joojisaa dhaqdhaqaaqa fumarate reductase, oo sidaas awgeed ka hortagga jiilka adenosine triphosphate, ugu dambeyntii keenta dhimashada dulin.
Si la mid ah sida mebendazole, iyada oo loo marayo keenista denaturation ee cytoplasmic microtubules ee dulin mindhicirka iyo ku xidhka tubulin, waxay sababtaa xidhmidda gaadiidka intracellular, taasoo keenta raasamaal ee xubnaha endocrine Golgi;cytoplasm ayaa si tartiib tartiib ah u milmay, taasoo keenta dhimashada ugu dambeysa ee dulinnada.
Alaabtani waxay si buuxda u dili kartaa ukunta hookworm, ukunta pinworm, ukunta dhogorta leh, ukunta gooryaanka iyo cysticercosis beedka waxayna qayb dili kartaa ukunta Ascaris.
Isticmaalka Caadiga ah
Albendazole waa daawo loo isticmaalo in lagu daweeyo caabuqyada ay sababaan dulin.Waxaa la siin karaa in lagu daweeyo caabuq maskaxeed naadir ah (neurocysticercosis) ama waxaa la siin karaa in lagu daweeyo caabuqa dulin ee keena shuban muhiim ah (microsporidiosis).
Isticmaalka Caafimaad
Albendazole waxay leedahay dhaqdhaqaaq balaadhan oo ka dhan ah nematodes mindhicirka iyo cestodes, iyo sidoo kale hargabka beerka Opisthorchis sinensis, Opisthorchis viverrini, iyo Clonorchis sinensis.Waxa kale oo si guul leh loogu isticmaalay Giardia lamblia.Waxaa si weyn loogu isticmaalaa adduunka oo dhan daawaynta caabuqa mindhicirka.Waxay wax ku ool u tahay sida daawaynta hal-door ah ee ascariasis, caabuqyada hookworm-ka cusub iyo kan hore, iyo trichuriasis.Dawaynta qiyaasta badan ee albendazole waxay baabi'inaysaa pinworm, threadworm, capillariasis, clonorchiasis, iyo cudurka hydatid.Waxtarka albendazole ka-hortagga Gooryaanka (cestodes) guud ahaan waa isbeddel badan oo aan la dareemin.Waxa kale oo ay wax ku ool u tahay daawaynta neurocysticercosis maskaxda iyo laf dhabarta, gaar ahaan marka la siiyo dexamethasone.Albendazole waxa lagula talinayaa in lagu daweeyo gnathostomiasis.
