Sharaxaad Gaaban:
Lambarka CAS: 1197-18-8
Qaaciddada molecular: C8H15NO2
miisaanka kelli: 157.21
Qaab dhismeedka kiimikada:
| Macluumaadka aasaasiga ah | |
| Magaca alaabta | Tranexamic acid |
| Darajo | Darajada Qurxinta |
| Muuqashada | Caddaan ama ku dhawaad cad, budada crystalline |
| Qiimayn | 99% |
| Nolosha shelf | 2 sano |
| Baakad | 25kg/durbaan |
| Guryaha Kiimikada | Waxay si xor ah ugu milmi kartaa biyaha iyo glacial acetic acid waxayna aad ugu milmaysaa ethanol oo si ficil ahaan aan loogu milmi karin ether |
Sharaxaada
Tranexamic acid waa nooc ka mid ah dawooyinka lidka-fibrinolytic-ka ah si loo joojiyo dhiigbaxa aminomethylbenzoic acid. Habka hemostasis ee tranexamic acid wuxuu la mid yahay aminocaproic acid iyo aminomethylbenzoic acid, laakiin saameyntu way ka xoog badan tahay. Awooddu waa 7 ilaa 10 jeer aminocaproic acid, 2 jeer aminomethylbenzoic acid, laakiin suntu waa la mid.
Qaab dhismeedka kiimikaad ee tranexamic acid wuxuu la mid yahay lysine, xannibaadda tartanka ee plasmin asalka ah ee xayeysiinta fibrin, si looga hortago firfircoonidooda, borotiinka fiber-ka ilaalinta inaysan hoos u dhigin plasmin oo ay milmaan, ugu dambeyntiina waxay gaaraan hemostasis. Lagu dabaqi karo daawaynta fibrinolytic hyperthyroidism aasaasiga ah ee ba'an ama dabadheeraad ah ee uu keeno dhiig-baxa, sida dhiigbaxa umusha, dhiigbaxa kelyaha, dhiigbaxa hypertrophy ee prostate ka, hemophilia, qaaxada sambabada hemoptysis, dhiigbax caloosha, ka dib qaliin beerka, sambabada , beeryarada iyo dhiigbaxa kale ee viscera; sidoo kale waxaa loo isticmaali karaa qaliinka marka dhiigbax aan caadi ahayn iwm.
Aashitada tranexamic ee kiliinikada waxay si weyn u saameyneysaa cudurrada qaniinyada cayayaanka, dermatitis iyo cambaarta, purpura fudud, urtikaria raaga, urtikaria galmada macmal ah, sunta dilaaca iyo dillaaca. Iyo sidoo kale waxay saameyn gaar ah ku leedahay erythroderma, scleroderma, lupus erythematosus (SLE), Erythema multiforme, shingles iyo alopecia areata. Daawaynta saamaynta anjioedema ee la iska dhaxlo sidoo kale waa wanaagsan tahay. Daawaynta Chloasma, daawaynta guud waxay wax ku oolaysaa ilaa 3 toddobaad, si muuqatana waxtar u leh 5 toddobaad, koorsada 60 maalmood. Waxaa lagu siiyaa afka qiyaas ah 0.25 ~ 0.5 g, maalintii 3 ~ 4 jeer. Qaar ka mid ah bukaannada ayaa lallabbo, daal, cuncun, calool xanuun, iyo shuban waxyeellooyin soo raaca ka dib marka calaamaduhu ay baaba'aan.
Tilmaamaha
Dhiigbaxyo kala duwan oo uu keeno hyperfibrinolysis aasaasiga ah ee ba'an ama dabadheeraad ah, deegaan ama habaysan; heerka labaad ee hyperfibrinolytic oo ay sababtay xinjirowga xididdada dhiigga ee faafa. Guud ahaan ha isticmaalin alaabtan ka hor intaan la helin heparinization.
Dhaawaca ama dhiigbaxa qalliin ee unugyada iyo xubnaha leh firfircoonayaasha plasminogen badan sida prostate, kaadi mareenka, sambabada, maskaxda, ilmo galeenka, qanjidhada adrenal, iyo tayroodh.
Ka soo horjeeda unugyada plasminogen activator (t-PA), streptokinase, iyo urokinase.
Dhiigbaxa fibrinolytic ee uu keeno ilmo iska soo ridid macmal ah, mandheerta oo go'an goor hore, dhalmada oo dhiman iyo embolism dheecaanka amniotic; iyo korodhka menorrhagia ee uu keeno fibrinolysis intrauterine pathological.
Dhiig-baxa khafiifka ah ee maskaxda ee neuropathy, sida dhiig-baxa subarachnoid iyo dhiig-baxa aneurysm intracranial, saameynta Amstat ee xaaladdan ayaa ka fiican tan wakiilada kale ee anti-fibrinolytic. Waa in fiiro gaar ah loo yeesho khatarta bararka maskaxda ama wadna xanuunka maskaxda.
Daaweynta bararka angioneurotic ee la iska dhaxlo, waxay yarayn kartaa tirada iyo darnaanta dhacdooyinka.
Loo isticmaalo bukaanada qaba hemophilia dhiigbaxa firfircoon ee ay la socdaan daroogooyinka kale.
Bukaannada Hemophilia oo leh cillad VIII ama factor IX ay ku yaraato ilig-soosaarkooda ama qalliinka afka haddii ay dhacdo dhiigbax qalliin.
