Sharaxaad Gaaban:
Lambarka CAS: 69004-03-1
Qaaciddada molecular: C18H14F3N3O4S
Miisaanka molecular: 425.38
Qaab dhismeedka kiimikada:
| Macluumaadka aasaasiga ah | |
| Magaca alaabta | Toltrazuril |
| CAS Maya. | 69004-03-1 |
| Midabka | Caddaan ama ku dhawaad cad budo crystalline |
| Darajo | Fasalka Quudinta |
| Kaydinta | Lagu xidhay qalalan, heerkulka qolka |
| Nolosha shelf | 2 sano |
| Isticmaal | Lo'da, Digaag, Ey, Kaluun, Faras, Doofaar |
| Xidhmada | 25kg/durbaan |
Sharaxaada
Toltrazuril (Baycox®, Procox®) waa daawada triazinon oo leh anticoccidial ballaaran iyo antiprotozoalactivity. Si ganacsi ahaan loogama helo Mareykanka, laakiin waxaa laga heli karaa wadamada kale. Waxay si firfircoon uga soo horjeedaa labada jinsi iyo marxaladaha galmoodka ee coccidia iyadoo la joojinayo qaybinta nukliyeerka ee schizonts iyo microga-mons iyo derbiyada samaynta macrogamont. Waxa kale oo laga yaabaa inay waxtar u leedahay daaweynta porcinecoccidiosis ee dhallaanka, EPM, iyo hepatozoonosis canine.
Toltrazuril iyo metabolite-ka ugu weyn ee ponazuril (toltrazuril sulfone, Marquis) waa dawooyinka antiprotozoal ee triazine ku salaysan oo leh waxqabad gaar ah oo ka dhan ah caabuqyada coccidial apicomplexan. Toltrazuril lagama heli karo gudaha Maraykanka.
Codsiga alaabta
Doofaarka: Toltrazuril ayaa la muujiyay si loo yareeyo calaamadaha coccidiosis ee doofaarka kalkaalinta dabiiciga ah ee cudurka qaba marka hal afka laga qaato 20-30 mg / kg BWdose la siiyo 3 ilaa 6-dayold doofaarka (Driesen et al., 1995). Calaamadaha kiliinikada ayaa laga dhimay 71 ilaa 22% ee doofaarka kalkaalinta, iyo shubanka iyo dheecaanka dheecaanka ayaa sidoo kale hoos u dhacay daaweynta afka keliya. Alaabooyinka la ansixiyay waxay wataan 77-maalmood wakhtiga ka bixida Boqortooyada Midowday.
Wayyaha iyo baraarka: Toltrazuril waxa loo isticmaalaa ka hortagga calaamadaha kiliinikada ee coccidiosis iyo yaraynta daadashada coccidia ee weylaha iyo baraarka sida hal qiyaas daawaynta. Waqtiyada ka bixida Boqortooyada Midowday (UK) waa 63 iyo 42 maalmood ee weylaha iyo waraha, siday u kala horreeyaan.
Eeyaha: Hepatozoonosis, toltrazuril oo afka laga siiyo 5 mg/kg BW 12 saacadood kasta 5 maalmood ama afka laga siiyo 10 mg/kg BW 12 saacadood kasta 10 maalmood waxay sababtay cafiska calaamadaha kiliinikada ee eeyaha si dabiici ah u buka 2-3 maalmood gudahood. Macintire iyo al., 2001). Nasiib darro, eyda la daweeyay badidood ayaa dib u soo noqday oo aakhirkii u dhintay hepatozoonosis. Eeyaha leh Isospora sp. infekshanka, daaweynta 0.45 mg emodepside oo lagu daray 9 mg/kg BW toltrazuril (Procox®, Bayer Animal Health) waxay yaraynaysaa tirada xiidmaha xiidmaha 91.5-100%. Ma jirin farqi u dhexeeya muddada shubanka markii daawaynta la bilaabay ka dib bilawga calaamadaha kiliinikada inta lagu jiro caabuqa patent (Altreuther et al., 2011).
Bisadaha: Kittens si tijaabo ah looga qaado Isospora spp., daawaynta hal dose oo afka laga qaato oo ah 0.9 mg emodepside oo ay weheliso 18 mg/kg BW toltrazuril (Procox®, Bayer AnimalHealth) waxa ay yaraynaysaa daadinta oocystka 96.7-100% haddii la bixiyo wakhtiga prepatentka muddada (Petry et al., 2011).
Fardaha: Toltrazuril waxa kale oo loo isticmaalay daawaynta EPM. Daawadani waa badbaado, xitaa marka la qaato qiyaaso badan. Daawaynta hadda lagu taliyay waa 5-10 mg/kg afka 28 maalmood. In kasta oo waxtarka wanaagsan ee toltrazuril, isticmaalkiisu wuu yaraaday fardaha sababtoo ah helitaanka dawooyin kale oo waxtar leh.
