Sharaxaad Gaaban:
CAS nambarka:55268-74-1
Qaacidada molecular:C19H24N2O2
miisaanka kelli: 312.41
Qaab dhismeedka kiimikada:
| Macluumaadka aasaasiga ah | |
| Magaca alaabta | Praziquantel |
| Darajo | darajada farmashiyaha |
| Muuqashada | Waa caddaan ama ku dhawaad cad budada crystalline |
| Qiimayn | 99% |
| Nolosha shelf | 2 sano |
| Baakad | 25kg/durbaan |
| Sifada | Si xor ah ugu milmay ethanol ama dichloromethane. Waxoogaa ku milmay biyaha |
| Xaalad | Waxaa lagu xidhay qalalan, ku kaydi qaboojiyaha, ka hooseeya -20 ° C |
Sharaxaada
Praziquantel (PZQ) waa soosaar isoquinoline oo leh inta badan dhaqdhaqaaqa noole ee laga helo levo eantiomer. Xaruntu ma laha wax dhaqdhaqaaq ah oo ka dhan ah nematodes, laakiin aad bay waxtar ugu leedahay cestodes iyo trematodes.
Farmashiistaha iyo habka ficilka
Praziquantel waa xarun pyrazinoquinoline oo asal ahaan loo sameeyay daawaynta schistosomiasis laakiin waxaa la ogaaday in uu leeyahay dhaqdhaqaaq balaadhan oo anthelminthic ah. Praziquantel waa jaalle laakiin R (+) enantiomer ayaa kaligii masuul ka ah hawsheeda kahortaga parasitic. Waxay ka soo horjeedaa trematodes (dhammaan noocyada Schistosoma ee u nugul nin, Paragonimus westermani, iyo Clonorchis sinensis) iyo cestodes (Taenia saginata, Taenia solium, Hymenolepis nana iyo Diphyllobothrium latum) .
Habka ficilka praziquantel si cad looma garanayo. Schistotosomes waxay si degdeg ah u qaataan daawada. Qaadashada mukhaadaraadka isla markiiba waxa ku xiga dhaqdhaqaaqa murqaha oo kordha kaas oo u socda foosha tetanic iyo faaruqinta tegument-ka dulinka .
Saamaynta murqaha ee daawada ayaa loo maleynayaa inay mas'uul ka tahay wareejinta dulinnada xididdada mesenteric ee beerka ee vivo. Si kastaba ha ahaatee, isbeddelka cagaarshow ayaa lagu soo bandhigay schistosomicides inta badan loo yaqaan waxaana laga yaabaa inaysan bixin wax macluumaad ah oo gaar ah oo ku saabsan habka daroogada. Natiijooyinka tijaabada ah ee ugu dambeeyay ayaa soo jeediyay in saameynta antischistosomal ee daawadu ay la xiriirto saameynta ay ku leedahay tegument-ka halkii ay ku yeelan lahayd murqaha.
Saamaynta kale ee dawooyinka ee daawadu waxaa ka mid ah korodhka xajinta xuubka ilaa cations, gaar ahaan kalsiyum.
Si kastaba ha noqotee, doorka saameyntan ee hantida anthelminthic ee daroogada lama garanayo.
Codsiga
Waa nooc ka mid ah dawada ka hortagga dulinka ee ballaaran. Waxaa loo isticmaali karaa daaweynta iyo ka hortagga schistosomiasis, cysticercosis, paragonimiasis, cudurka hydatid, fasciolopsiasis, cudurka hydatid, iyo caabuqa gooryaanka.
Waxa kale oo loo isticmaali karaa sida anthelmintic waxayna wax ku ool u tahay daaweynta nematodes-ka mindhicirka xoolaha. Waxaa lagu qasi karaa quudinta codsiga.
Alaabtu waa nooc ka mid ah dawada anthelmintic oo wax ku ool u ah daawaynta Schistosoma japonicum, Schistosoma mansoni iyo Schistosoma haematobium, Clonorchis sinensis, Paragonimus westermani, fasciolopsis buski, gooryaanka tapeworms iyo cysticercosis. Waxay si gaar ah u leedahay saameyn dil ah oo xooggan oo ku saabsan gooryaanka waxayna hadda ugu waxtarka badan tahay dawada ka hortagga schistosomiasis.
Waa nooc ka mid ah daawada anthelmintics ee inta badan loo isticmaalo daawaynta schistosomiasis. Waxa kale oo loo isticmaali karaa daawaynta Fahrenheit schistosomiasis, taeniasis, paragonimiasis, iyo cysticercosis
