Sharaxaad Gaaban:
Lambarka CAS: 1264-72-8
Qaaciddada molecular: 2 (C52H98N16O13).5 (H2SO4)
Miisaanka molecular: 2801.27
Qaab dhismeedka kiimikada:
| Macluumaadka aasaasiga ah | |
| Magaca alaabta | Colistin sulfate |
| Darajo | Fasalka Quudinta |
| Muuqashada | Caddaan ama ku dhawaad cad, budada hygroscopic |
| Qiimayn | 99% |
| Nolosha shelf | 2 sano |
| Baakad | 20kg/kartoon 20kg/durbaan |
| Xaalad | Ku kaydi at -20℃ hal sano(Budada) |
Sharaxaada alaabta
Colistin waa decapeptide cationic ah oo wareeg ah oo ku xiran silsilad dhinaca aashitada dufanka leh, waxay ka tirsan tahay koox ka kooban peptides-ka bakteeriyada antimicrobial ee isku mid ah. Colistin sulfate waa antibiyootig polypeptide ah kaas oo ka hortagaya bakteeriyada garaam-negative iyada oo ku xidhan lipopolysaccharides iyo phospholipids ee xuubka unugyada dibadda ee bakteeriyada gram-negative.
Colistin sulfate, oo sidoo kale loo yaqaan colistin sulfate, Christian (Colistin), Polymyxin E (Polymyxin E), antiphytin, cad ama budo cad oo ku dhow, ur aan lahayn, qoyaan dhadhan qadhaadh, si fudud ugu milmi biyaha, wax yar oo ku milma methanol, ethanol, ku dhawaad aan la karin acetone, ether, alkali lacag la'aan ah wax yar ku milmay biyaha. Deggan PH3-7.5 Mycolistin sulfate waxaa soo saara Bacillus polymyxoides, kaas oo saameyn xooggan ku leh bakteeriyada gram-negative. Waxaa loo isticmaalaa in lagu daaweeyo cudurrada mindhicirka ee ay keento bakteeriyada garaam-negative, waxaana loo isticmaalaa sida wax lagu daro quudinta oo leh saameyn cad oo kor u qaadis ah. Isku dhafka saameynta sulfadiazine ayaa ka fiican.
Shaqada alaabta
Colistin sulfate granules waxay wanaajisay xasilloonida awoodda quudinta waxayna soo bandhigaysaa milmayn sare inkasta oo la soo saaray iyada oo aan la isticmaalin wax qaade qaali ah ama qalab gaar ah. Gaar ahaan, colistin sulfate granules oo ka kooban asal ahaan colistin sulfate oo leh dhexroorka qayb ka mid ah 150 ilaa 1500m, aag gaar ah oo ah 40 ilaa 500 cm2 / g, wakhti qoynta 5 daqiiqo ama ka hooseeya iyo qoyaanka 10 % ama ka hooseeya.
Pharmacodynamics
Colistin waa wakiilka antibiyootiga polymyxin. Polymyxins waa polypeptides cationic kuwaas oo carqaladeeya xuubka unugyada bakteeriyada iyada oo loo marayo habka saabuunta oo kale ah. Iyada oo la kobciyo walxaha sunta ah ee yar yar, sida penicillins-ka fidsan iyo cephalosporins, isticmaalka parenteral polymyxin ayaa inta badan laga tagay, marka laga reebo daaweynta caabuqyada sambabada ee u adkaysta daawooyinka badan ee bukaanka qaba cystic fibrosis.
