Sharaxaad Gaaban:
Lambarka CAS:24729-96-2
Qaacidada molecular:C18H34ClN2O8PS
miisaanka kelli: 504.96
Qaab dhismeedka kiimikada:
| Macluumaadka aasaasiga ah | |
| Magaca alaabta | Clindamycin Phosphate |
| Darajo | darajada farmashiyaha |
| Muuqashada | budo cad |
| Qiimayn | 95% |
| Nolosha shelf | 2 sano |
| Baakad | 25kg/durbaan |
| Xaalad | Deggan, laakiin kaydi qabow. Aan ku habboonayn wakiilada oksaydhiyeyaasha xooggan, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, fitamiinada kooxda B ee sodium. |
Sharaxaada
Clindamycin fosfate waa ester biyo-milmi leh oo ka mid ah antibiyootiga semisynthetic oo ay soo saartay 7 (S) -chloro-beddelka kooxda 7 (R) -hydroxyl ee antibiyootiga waalidka, lincomycin. Waa nooc ka mid ah lincomycin (lincosamide). Waxay leedahay ficil bacteriostatic ah oo ka dhan ah aerobeska Gram-positive iyo tiro balaadhan oo ah bakteeriyada anaerobic. Waa antibiyootiko jirka la mariyo oo loo isticmaalo daawaynta caabuqyada. Kuwaas waxaa ka mid noqon kara infekshannada habka neefsashada, septicaemia, peritonitis iyo caabuqyada lafaha. Waxa kale oo loo isticmaalaa in lagu daweeyo finanka dhexdhexaadka ah iyo kuwa daran.
Isticmaal
Fosfooraska Clindamycin waxa loo isticmaalaa meel kaligiis ah ama iyada oo lala kaashanayo benzoyl peroxide daawaynta vulgaris finan barar ah. Marka la miisaamo faa'iidooyinka suurtagalka ah ee daaweynta clindamycin ee jirka la mariyo, suurtagalnimada saameyn xun oo GI ah oo la xiriirta daawada waa in la tixgeliyaa. Daaweynta finanka vulgaris waa in ay noqotaa mid gaar ah oo si joogta ah wax looga beddelo iyadoo ku xiran noocyada nabarrada finanka ee u badan iyo jawaabta daawaynta. Ka hortagga caabuqyada jirka la mariyo, oo ay ku jirto clindamycin, guud ahaan waxay wax ku ool u yihiin daawaynta finanka bararka fudud ilaa dhexdhexaad. Si kastaba ha ahaatee, isticmaalka daawooyinka ka hortagga jeermiska ee jirka sida monotherapy waxay u horseedi kartaa caabbinta bakteeriyada; iska caabintan waxay la xiriirtaa hoos u dhaca waxtarka bukaan-socodka. Natiijooyinka daraasadaha caafimaadku waxay muujinayaan in daaweynta isku dhafan ay keento hoos u dhaca tirada guud ee nabarrada 50-70%.
Clindamycin 2-fosfate waa milix ka mid ah clincamycin, lincosamide semi-synthetic. Milixda waxaa lagu diyaariyaa fosforyaal la xushay oo ah 2-hydroxy moiety ee sonkorta clindamycin. Soo bandhigida fosfooraska waxa ay sahlaysaa in la wanaajiyo milanka habaynta la isku duro. Sida xubnaha kale ee qoyska lincosamide, clindamycin 2-fosfate waa antibiyootig ballaadhan oo firfircoon oo ka dhan ah bakteeriyada anaerobic iyo protozoans. Clindamycin wuxuu u shaqeeyaa isagoo ku xiraya 23S ribosomal subunit, xannibaya isku-darka borotiinka.
