Sharaxaad Gaaban:
Lambarka CAS: 38821-53-3
Qaaciddada molecular: C16H19N3O4S
miisaanka kelli: 349.4
Qaab dhismeedka kiimikada:
| Macluumaadka aasaasiga ah | |
| Magaca alaabta | Cefradine |
| Xasilooni | Iftiinka xasaasiga ah |
| Muuqashada | budo cad |
| Qiimayn | 99% |
| barta dhalaalaysa | 140-142 C |
| Baakad | 5KG; 1KG |
| Barta karkarinta | 898℃ |
Sharaxaada
Cefradine (oo sidoo kale loo yaqaano cephradine), 7-[D-2-amino-2(1,4cyclohexadien1-yl) acetamido]-3-methyl-8-0x0-5thia-l-azabicyclo[4.2.0] oct-2- ene-2-carboxylic acid monohydrate (111 waa antibiyootig cephalosporin semi-synthetic ah. loo isticmaalo afka, muruqyada, iyo xididada. Qaab dhismeedka cephradine wuxuu la mid yahay kan cephalexin, farqiga kaliya ee ku jira giraanta lix xubnood ah. Cephalexin wuxuu leeyahay saddex labajibbaaran bonds samaynta hab udgoon halka cephradine uu leeyahay laba bond bond ee isku giraanta ah[1].
Jaantuska1 qaabdhismeedka kiimikada ee cefradine;
Cephradine waa budo crystalline cad oo miisaankeedu yahay 349.4[2]. Isku-dubbaridka cephradine ayaa laga wada hadlay[3]. Cephradine waxay si xor ah ugu milmi kartaa dareerayaasha aqueous. Waa zwitterion, oo ka kooban labada koox amino alkaline ah iyo koox karboksyl acidic ah. Qiyaasta pH ee 3-7, cephradine waxay u jirtaa milix gudaha ah[4]. Cephradine waxay ku xasilloon tahay saacadaha 24 ee 25" gudaha pH ee 2-8. Maadaama ay ku xasilloon tahay warbaahinta acidic, waxaa jira wax yar oo lumay dhaqdhaqaaqa dareeraha gastric; khasaaraha wax ka yar 7% ayaa la soo sheegay[5].
Cephradine si liidata ayuu ugu xidhan yahay borotiinnada serum-ka. Daawadu waxay ku xidhnayd in ka yar 20% borotiinada serum[4]. Marka la eego qiyaasta serum ee 10-12 pg / ml, 6% wadarta daawada waxay ku jirtay isku-xidhka borotiinka. Daraasad kale[6]waxaa la ogaaday in wadarta guud ee 10 pg / ml, 28% daawadu ay ku jirtay gobolka borotiinka; wadarta guud ee 100 pg / ml, 30% daawadu waxay ku jirtay xaalada borotiinka. Daraasaddan ayaa sidoo kale muujisay in ku darida serum ee cephradine ay hoos u dhigtay dhaqdhaqaaqa antibiyootiga. Daraasad kale[2]waxay muujisay in isku-xidhka borotiinka ee cephradine uu kala duwan yahay 8 ilaa 20%, taas oo ku xidhan xoojinta daawada. Si kastaba ha ahaatee, daraasad uu sameeyay Gadebusch et al.[5]wax isbeddel ah lagama helin MIC ee cephradine dhinaca Staphylococcus aureus ama Escherichia coli ka dib marka lagu daro serumka bini'aadamka.
Tilmaamaha
Cephradine waxay u firfircoon tahay in vitro ka soo horjeeda noocyo ballaadhan oo bakteeriyada garaam-positive ah iyo garaam-negative, oo ay ku jiraan noolaha pathogenic ee ku go'doonsan rugta caafimaadka; Xarunta ayaa lagu muujiyay inay xasilloon tahay aashitada, iyo ku-darka serum-ka bini'aadamka waxay saameyn yar ku yeelatay diiradda ugu yar ee xakamaynta (MIC) ee noolaha xasaasiga ah. Marka afka ama hoosta laga siiyo xayawaanka si tijaabo ah loogu qaaday bakteeriyada kala duwan ee bakteeriyada, cephradine waxay bixisay difaac waxtar leh.[16]. Daawaynta cudurrada faafa ee degdega ah, jawaabaha kiliinikada ee lagu qanco ee daaweynta cephradine ayaa waxaa soo sheegay tiro baarayaal ah.[14, 15, 17-19].
