Sharaxaad Gaaban:
Lambarka CAS: 27164-46-1
Qaaciddada molecular: C14H15N8NaO4S3
miisaanka kelli: 478.5
Qaab dhismeedka kiimikada:
| Macluumaadka aasaasiga ah | |
| Magaca alaabta | Cefazolin sodium cusbo |
| CAS Maya. | 27164-46-1 |
| Muuqashada | Caddaan ama Off-cad budada crystalline |
| Darajo | Farmaajo Fasalka |
| Kaydinta | Ku hay meel mugdi ah, jawi aan fiicneyn, 2-8 ° C |
| Nolosha shelf | 2 sano |
| Xasilooni | Deggan, laakiin waxa laga yaabaa inay dareento kulaylka - ku kaydi xaalado qabow. Waxaa laga yaabaa in midabkiisu is beddelo marka iftiinka uu soo baxo - ku kaydi mugdiga. Aan ku habboonayn walxaha oksaydhaynta ee xooggan. |
| Xidhmada | 25kg/Durbaan |
Sharaxaada Alaabta
Antibiyootig semi-synthetic ah oo ka kooban cephalosporins oo ku jira molecule cephalosporins. Waxaa loo tarjumay sida Xianfeng mycin. iska leh β-Antibiyootikada Lactam, haa β- Ka-soo-saareyaasha 7-aminocephalosporanic acid (7-ACA) ee ku jira antibiyootiga lactam waxay leeyihiin habab bakteeriyada la mid ah. Daawadu waxay burburin kartaa gidaarka unugga bakteeriyada waxayna dili kartaa xilliga dhalmada. Waxay leedahay saameyn xoog leh oo xulashada bakteeriyada iyo ku dhawaad ma laha sunta bini'aadamka, oo leh faa'iidooyin ay ka mid yihiin bakteeriyada bakteeriyada ballaaran, saameyn bakteeriyada xooggan, caabbinta enzymes penicillin, iyo dareen-celin xasaasiyadeed oo yar marka loo eego penicillin. Markaa waa antibiyootig muhiim ah oo leh waxtar sare, suntu hooseyso, iyo codsi caafimaad oo ballaaran. Cephalosporins jiilkii ugu horreeyay ayaa hore loo soo saaray, oo leh firfircooni bakteeriyada ka xoog badan marka la barbar dhigo Kiimikada, bakteeriyada bakteeriyada cidhiidhi ah, iyo saamaynta bakteeriyada Gram ka fiican oo ka fiican bakteeriyada Gram negative. Waxa soo saara Staphylococcus aureus β- Lactamase waa xasiloon oo waxay joojin kartaa soo saarista bakteeriyada taban β-Lactamases waa kuwo aan degganayn oo ay weli soo saari karaan bakteeriyada badan ee Gram negative β- Waxaa waxyeello u geystay lactamases. Cefazolin sodium waa cephalosporin jiilkii kowaad ee semi synthetic kaas oo leh saameyn lid ku ah bakteeriyada garaam-positive iyo gram-negative labadaba. Waxaa caadi ahaan loo isticmaalaa infekshannada habka neefsashada, habka kaadiheysta, unugyada jilicsan maqaarka, lafaha iyo kala-goysyada, iyo mareenka biliary ee ay keento bakteeriyada xasaasiga ah, iyo sidoo kale endocarditis, sepsis, pharyngeal iyo caabuqyada dhegta. Waxay leedahay firfircooni xoog leh oo ka dhan ah bakteeriyada garaam-positive sida Staphylococcus aureus iyo Streptococcus (marka laga reebo Enterococcus), waxayna ka sareysaa cephalosporins jiilka labaad ee saddexaad.
Isticmaalka Kiimikada
Cefazolin (Ancef, Kefzol) waa mid ka mid ah taxane semisyntheticcephalosporins kaas oo shaqada C-3 acetoxy lagu beddelay heterocycle-ka kooban thiol-halkan, 5-methyl-2-thio-1,3,4-thiadiazole. Waxa kale oo ku jira kooxda acylating tetrazolylacetyl xoogaa aan caadi ahayn. Cefazolin ayaa la sii daayay 1973-kii iyada oo ah cusbo sodium ah oo biyo-milmi leh. Waxaa si firfircoon u maamula waalidnimada.
Cefazolin waxay bixisaa heerarka serum sare, kalyaha oo gaabis ah, iyo cimri badh ka dheer kuwa kale-jiilka kowaad eecephalosporins. Waxay ku dhowdahay 75% borotiinka ku xidhan inplasma, qiimo sare marka loo eego inta badan cephalosporins kale. Horaantii in vitro iyo daraasaadka kiliinikada waxay soo jeedinayaan in cefazolin uu aad uga firfircoon yahay bacilli Gram-negative laakiin ka firfircoonida Cocci Gram-positive marka loo eego cephalothin amacephaloridine midkood. Heerarka dhacdooyinka thrombophlebitis ka dib cirbadeynta xididka iyo xanuunka goobta muruqa intramusculara ayaa u muuqda kuwa ugu hooseeya ee parenteralcephalosporins.
