Sharaxaad Gaaban:
Lambarka CAS:590-63-6
Qaaciidada molecular:C7H17ClN2O2
miisaanka kelli:196.68
Qaab dhismeedka kiimikada:
| Macluumaadka aasaasiga ah | |
| Magaca alaabta | Bethanechol |
| Darajo | darajada farmashiyaha |
| Muuqashada | budo cad |
| Qiimayn | 95% |
| Nolosha shelf | 2 sano |
| Baakad | 25kg/durbaan |
| Xaalad | Meel qabow oo qallalan |
Sharaxaada
Bethanechol waa ester synthetic qaab-dhismeed ahaan iyo dawo ahaan la xidhiidha acetylcholine. Muscarinic a tartiib tartiib ah hydrolyzed oo aan lahayn saameyn nicotinic ah, Bethanechol guud ahaan waxaa loo isticmaalaa in lagu kordhiyo murqaha siman, sida habka GI ka dib qalliinka caloosha ama haynta kaadida ee maqnaanshaha xannibaadda. Waxay keeni kartaa hypotension, isbeddelada heerka wadnaha, iyo maro bronki ah.
Bethanechol waa agonist muscarinic acetylcholine reseptors oo leh IC50 qiyamka 1,837, 25, 631, 317, iyo 393 μM ee M1-5, siday u kala horreeyaan, baaritaanka radioligand xidhitaanka iyadoo la adeegsanayo unugyada CHO oo muujinaya soo-dhoweynta aadanaha. Waxay ka hortagtaa korodhka M2-dhexdhexaadinta ee AMP wareegta ah oo ay keentay isoproterenol ee xiidmaha yar ee doofaarka guinea ee go'doonsan (IC50 = 127 μM). Bethanechol waxay kordhisaa codka asalka ah ee kaadi mareenka galmoodka go'doonsan (EC50 = 4.27 μM). Waxa kale oo ay kicisaa dheecaanka dareeraha ee ileum, duodenum, iyo jejunum ee jiirka la suuxiyay marka la qaato qiyaasta 60 μg/kg. Daawooyinka ay ku jiraan bethanechol ayaa loo isticmaalay si loo kordhiyo kaadida iyo hagaajinta murqaha siman ee mareenka caloosha iyo mindhicirka.
Isticmaalka Caafimaad
Isticmaalka ugu muhiimsan ee chloride bethanechol waxay ku jirtaa nasinta haynta kaadida iyo calool-xanagga qalliinka kadib. Waa inaan waligiis lagu maamulin cirbadeynta muruqa ama xididada sababtoo ah khatarta ka imanaysa kicinta cholinergic iyo luminta ficil xulashada. Maamulka saxda ah ee dawadu waxay la xiriirtaa sunta oo yaraata oo aan lahayn waxyeelo halis ah. Bethanechol chloride waa in si taxadir leh loo isticmaalo bukaanada neefta qaba; Marka loo isticmaalo glaucoma, waxay soo saartaa madax-xanuun xagga hore ah oo ka yimaada ciriiriga muruqa sfincter-ka ee isha iyo murqaha muruqyada ciliary. Muddada ficilkeedu waa 1 saac.
Daawooyinka iyo Daawaynta Xoolaha
Daawada caafimaadka xoolaha, bethanechol waxa loo isticmaalaa in lagu kiciyo foosha kaadiheysta ee xayawaanka yaryar. Waxa kale oo loo isticmaali karaa kicinta hunguriga ama guud ahaan GI, in kasta oo metoclopramide iyo/ama neostigmine ay si weyn ugu beddeleen isticmaalkan.
